Research Behind Our Ingredients



Bacillus

Rhayat L, Maresca M, Nicoletti C, et al. Effect of Bacillus subtilis Strains on Intestinal Barrier Function and Inflammatory Response. Front Immunol. 2019 Mar 29;10:564.

Elshaghabee FMF, Rokana N, Gulhane RD, et al. Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives. Front Microbiol. 2017 Aug 10;8:1490.



Bentonite Clay

Moosavi M. Bentonite Clay as a Natural Remedy: A Brief Review. Iran J Public Health. 2017 Sep;46(9):1176-1183.



Burdock Root

Chan YS, Cheng LN, Wu JH, et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011 Oct;19(5):245-54.



Cabbage Juice

Garnett Cheney. Rapid healing of peptic ulcers in patients receiving fresh cabbage juice. Calif Med. 1949 Jan;70(1):10-5.



CBD Oil

Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011 May;36(6):1219-26.

Crippa JA, Derenusson GN, Ferrari TB, et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol. 2011 Jan;25(1):121-30.

Lukhele ST, Motadi LR. Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC Complement Altern Med. 2016 Sep 1;16(1):335.

Fraguas-Sánchez AI, Fernández-Carballido A, Torres-Suárez AI. Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas. Expert Opin Investig Drugs. 2016 Nov;25(11):1311-1323.

Orrin Devinsky, Joseph Sullivan, Daniel Friedman, et al. Efficacy And Safety Of Epidiolex (Cannabidiol) In Children And Young Adults With Treatment-Resistant Epilepsy: Initial Data From An Expanded Access Program. AES Abst. 2014;3.303.

Carlini EA, Cunha JM. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol. 1981 Aug-Sep;21(S1):417S-427S.

Xiong W, Cui T, Cheng K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med. 2012 Jun 4;209(6):1121-34.



Chaga

Arata S, Watanabe J, Maeda M, et al. Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice. Heliyon. 2016 May 12;2(5):e00111.

Nomura M, Takahashi T, Uesugi A, et al. Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res. 2008 Sep-Oct;28(5A):2691-6.



Chlorella

Merchant RE, Andre CA. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med. 2001 May-Jun;7(3):79-91.



Colostrum

Hurley WL, Theil PK. Perspectives on immunoglobulins in colostrum and milk. Nutrients. 2011 Apr;3(4):442-74.

R. Pakkanen, J. Aalto. Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal. 1997 May;7(5):285-97.

Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut. 1999 May;44(5):653-8.

Raymond J Playford, Christopher E Macdonald, Wendy S Johnson. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. American Journal of Clinical Nutrition. 2000 Aug;72(1):5-14.

Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, et al. Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35(5):557-66.

Giffard CJ, Seino MM, Markwell PJ, Bektash RM. Benefits of bovine colostrum on fecal quality in recently weaned puppies. J Nutr. 2004 Aug;134(8 Suppl):2126S-2127S.



Cordyceps

Ji DB, Ye J, Li CL, et al. Antiaging effect of Cordyceps sinensis extract. Phytother Res. 2009 Jan;23(1):116-22.

Won SY, Park Eh. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. Journal of Ethnopharmacology. 2005 Feb;96(3):555-61.



Dandelion

Mingarro DM, Plaza A, Galán A, et al. The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity. Food Funct. 2015 Aug;6(8):2787-93.

Ovadje P, Ammar S, Guerrero JA, et al. Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget. 2016 Nov 8;7(45):73080-73100.



Eggshell Membrane

Ruff KJ, Kopp KJ, Von Behrens P, et al. Effectiveness of NEM® brand eggshell membrane in the treatment of suboptimal joint function in dogs: a multicenter, randomized, double-blind, placebo-controlled study. Vet Med (Auckl). 2016 Aug 18;7:113-121.



Fulvic Acid

John Winkler, Sanjoy Ghosh. Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes. J Diabetes Res. 2018 Sep 10;2018:5391014.

Vucskits AV, Hullár I, Bersényi A, et al. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl). 2010 Dec;94(6):721-8.

 


Green Lipped Muscles

Rialland P, Bichot S, Lussier B, et al. Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Can J Vet Res. 2013 Jan;77(1):66-74.



Humic Acid

Wollina U. Peat: a natural source for dermatocosmetics and dermatotherapeutics. J Cutan Aesthet Surg. 2009 Jan;2(1):17-20.

Vucskits AV, Hullár I, Bersényi A, et al. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl). 2010 Dec;94(6):721-8.

 


Maitake

Sensuke Konno. Potential growth inhibitory effect of maitake D-fraction on canine cancer cells. Vet Ther. 2004 Winter;5(4):263-71.



Phellinus

Daniel Sliva. Medicinal mushroom Phellinus linteus as an alternative cancer therapy. Exp Ther Med. 2010 May;1(3):407-411.

Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm. 2014;2014:805841.



Reishi

Sun LX, Lin ZB, Li XJ, et al. Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to activate lymphocytes. Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):149-54.



Saccharomyces boulardii

Mustafa Sinan Aktas, Mehmet Kazim Borku1, Yunusemre Ozkanlar. Efficacy of Saccharomyces boulardii as a probiotic in dogs with lincomycin induced diarrhoea. Bull Vet Inst Pulawy. Jan 2007;51(3):365-369.



Shiitake

Morales D, Rutckeviski R, Villalva M, et al. Isolation and comparison of α- and β-D-glucans from shiitake mushrooms (Lentinula edodes) with different biological activities. Carbohydr Polym. 2020 Feb 1;229:115521.

Ina K, Kataoka T, Ando T. The use of lentinan for treating gastric cancer. Anticancer Agents Med Chem. 2013 Jun;13(5):681-8.



Turkey Tail

Dorothy Cimino Brown, Jennifer Reetz. Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma. Evid Based Complement Alternat Med. 2012;2012:384301.

Eliza WL1, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):78-87.

Annoor Awadasseid, Jie Hou, Yaser Gamallat, et al. Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus Versicolor. PLoS One. 2017 Feb 8;12(2):e0171270.